Know How Wakix Stacks Up Against Other Narcolepsy Meds

Wakix (WAY-kiks, pitolisant) will be the first NONcontrolled substance for excessive daytime sleepiness due to narcolepsy.

It joins armodafinil (Nuvigil), modafinil (Provigil), and Sunosi (solriamfetol). These are C-IV meds...and are also approved for excessive sleepiness due to obstructive sleep apnea.

Wakix is thought to increase histamine in the brain. Other meds that promote wakefulness likely impact dopamine or norepinephrine.

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