the best way to calculate creatinine clearance (CrCl) for dosing renally eliminated drugs

Questions often come up about the best way to calculate creatinine clearance (CrCl) for dosing renally eliminated drugs.

The Cockcroft-Gault equation is still the preferred method...and is what drug manufacturers use to determine renal dosing.

But it was developed using mostly "average" men...healthy, middle-aged, and about 70 kg. So it's not always accurate in under- or overweight patients, older patients, etc.