Know When to Call and When to Monitor for Serotonin Syndrome
Drug interaction alerts continue to cause confusion about when to recommend changing therapy due to the risk of serotonin syndrome.
Think of serotonin syndrome as "serotonin overload" caused by high doses...multiple serotonergic drugs...or drug interactions. The higher the load, the greater the risk.
The good news is that full-blown serotonin syndrome...with hyperthermia, muscle rigidity, and even death...is EXTREMELY rare.