new dosing recommendations for oral nitrates
Many physicians aren't aware of the new dosing recommendations for oral nitrates...even though they're already in many of the package inserts.
Nitrates work best when there's a long nitrate-free interval. This prevents tolerance...and a return of angina.
The old recommendation was for an 8-hour nitrate-free interval for oral nitrates...that's been increased to at least 14 hours.