guanfacine (Tenex) might precipitate mania
Experts are now cautioning that guanfacine (Tenex) might precipitate mania...in some children being treated for attention deficit hyperactivity disorder (ADHD).
Guanfacine is often used as an alternative to clonidine for ADHD and tic disorders. It has a longer duration...and causes less sedation and cardiovascular side effects than clonidine.
But some children on guanfacine become MORE agitated...with increased hyperactivity, incessant talking, excessive irritability, and insomnia.