caffeine might reduce the efficacy of methotrexate for rheumatoid arthritis

There's concern that caffeine might reduce the efficacy of methotrexate for rheumatoid arthritis.

Methotrexate decreases inflammation by increasing adenosine levels. Caffeine might cause a problem...because it's an adenosine receptor ANTAGONIST.

It's going to take time to figure out how significant this is.

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