the interaction between simvastatin (Zocor, etc) and amlodipine (Norvasc, etc)

New alerts are bringing up questions about the interaction between simvastatin (Zocor, etc) and amlodipine (Norvasc, etc).

Some people are surprised...because amlodipine is only a weak inhibitor of simvastatin metabolism by CYP3A4.

But the combo IS associated with a higher risk of myopathy.

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