warnings about codeine toxicity, especially in kids
June 2012
Please see FDA's Aug 2012 safety communication concerning codeine use in certain children
Codeine is a prodrug that's not active until it's metabolized to morphine by CYP2D6 enzymes. But 2D6 activity varies.
Up to 10% of Caucasians and up to 30% of some other races are ultrarapid metabolizers. They produce HIGHER morphine levels...increasing their risk of toxicity.
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