Recommend Praxbind to Reverse Pradaxa In Patients With Life-Threatening Bleeding
Praxbind (PRAKS-bynd, idarucizumab) will be the first reversal agent for ONE of the direct oral anticoagulants.
We know that vitamin K reverses bleeding due to warfarin...but not direct oral anticoagulants. So managing bleeding with these has been limited to stopping the drug, supportive care, using blood products, etc.
Praxbind is an IV monoclonal antibody fragment that binds to the thrombin inhibitor, Pradaxa (dabigatran), to reverse anticoagulation.