Watch for Ketoacidosis With Flozins

July 2015

See updated FDA information (December 2015) concerning SGLT2 inhibitors (Flozins) and ketoacidosis/urinary tract infections.

Colleagues will ask you whether Invokana (canagliflozin) and other SGLT2 inhibitors or "flozins" are linked to ketoacidosis.

This seems to be a flozin class effect...and has researchers scratching their heads about the mechanism.

It's different from the ketoacidosis we typically see with VERY high blood glucose. It's happening in patients with type 1 or 2 diabetes when glucose levels are near normal or only slightly elevated.

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