Plan Your Strategy to Reverse Warfarin or DOAC Bleeds

You'll need to determine the best way to reverse major bleeding caused by oral anticoagulants...as experts continue to debate.

First, stop the anticoagulant...and use supportive bleeding control measures. Add a reversal agent for life-threatening or critical site bleeds (intracranial, retroperitoneal, etc).

Warfarin. Generally use 4-factor prothrombin complex concentrate (Kcentra)...plus IV vitamin K.

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