substitution for "narrow therapeutic index" (NTI) drugs
December 1997
The new generic warfarin is raising a big controversy about substitution for "narrow therapeutic index" (NTI) drugs.
It's true that some drugs have a narrow range between doses that are subpotent...and doses that are toxic. Warfarin is one.
There are others...carbamazepine...digoxin...levothyroxine...phenytoin...theophylline.
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