possible interaction between Aricept (donepezil) and Paxil (paroxetine)
February 2000
New reports suggest a possible interaction between Aricept (donepezil) and Paxil (paroxetine).
This is important. Alzheimer's patients commonly develop mood disorders that are treated with antidepressants.
Paxil is a potent cytochrome P450 2D6 inhibitor that may slow the metabolism of Aricept. Increased Aricept levels can lead to insomnia...confusion...severe diarrhea, etc.
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